Female survivors of breast cancer living in the most deprived areas are at a significantly higher risk of developing second, unrelated cancers compared to those in more affluent areas, according to new research.
A study led by the University of Cambridge analyzed data from nearly 600,000 patients in England and found that women who had survived breast cancer had an increased risk of developing 12 other primary cancers. These included a doubled risk of cancer in the unaffected breast, an 87% higher risk of endometrial cancer, a 58% increased likelihood of myeloid leukemia, and a 25% higher risk of ovarian cancer.
The research, published in Lancet Regional Health – Europe, also revealed that the risk of second primary cancers was higher in individuals living in areas of greater socioeconomic deprivation. Compared to the most affluent survivors, those from the least well-off areas had a 166% greater chance of developing lung cancer, a 78% higher risk of stomach cancer, and more than 50% increased risk of bladder and esophagus cancers, among others.
The study’s first author, Isaac Allen, emphasized the need for further research to identify the specific factors driving these disparities and how to reduce them. He stated, “Many cancers are caused by deprivation, but more research is clearly needed to identify the specific factors driving the higher risks and how best to reduce these inequalities.”
In response to the findings, Prof Pat Price, a leading oncologist and co-founder of the Catch Up With Cancer campaign, highlighted the urgent need for a dedicated cancer plan to address the alarming inequalities within cancer care. Dr. Simon Vincent, the director of research, support, and influencing at Breast Cancer Now, emphasized the importance of investigating the causes of second primary cancers and improving follow-up care for breast cancer survivors.
The study also examined the risk of second primary cancers in male breast cancer survivors, finding that they were significantly more likely than the general male population to develop certain cancers. These findings underscore the importance of addressing disparities in cancer care and ensuring that all survivors receive appropriate follow-up care and support.